[Plasma and urine beta-thromboglobulin determination in the detection of thrombocyte hyperactivation in diabetic nephropathies]. / A plasma és a vizelet béta-thromboglobulin meghatározás a diabeteses nephropathiát kísérö thrombocyta hyperaktiváció kimutatásában.
Orv Hetil
; 132(21): 1135-8, 1141, 1991 May 26.
Article
en Hu
| MEDLINE
| ID: mdl-1828563
Serum creatinine, immunoreactive serum and urine beta-2-microglobulin, plasma and urine thromboglobulin, plasma thromboxane-B2 levels and daily protein excretion were determinated in 61 insulin treated diabetic patients, comparing the different patient groups (complication free, nephropathy without azotaemia and nephropathy with azotaemia) with the control subjects. In the groups of all diabetic patients plasma and urine beta-thromboglobulin and plasma thromboxane-B2 levels were higher that in the controls. There was a positive significant correlation between urine beta-thromboglobulin and beta-2-microglobulin in the group without complication, and between the plasma beta thromboglobulin and beta-2-microglobulin, and plasma beta thromboglobulin and thromboxane levels in the diabetic group with azotaemia. In contradiction to some previous assumptions, the increased level of plasma beta-thromboglobulin reflects a real platelet hyperactivation also in patients with diabetic nephropathy. At the same time urine beta-thromboglobulin also increases. Determination of urine beta-thromboglobulin is more simple with less possibility of methodological error.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Beta-Tromboglobulina
/
Diabetes Mellitus Tipo 1
/
Nefropatías Diabéticas
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
Hu
Revista:
Orv Hetil
Año:
1991
Tipo del documento:
Article
Pais de publicación:
Hungria