Next generation adoptive immunotherapy--human T cells as carriers of therapeutic nanoparticles.
J Nanosci Nanotechnol
; 7(12): 4575-80, 2007 Dec.
Article
en En
| MEDLINE
| ID: mdl-18283847
An important step in adoptive immunotherapy in general and specifically with respect to cancer treatment is the initiation of an inflammatory T cell response at the tumor site. Here we suggest a new concept for a controlled inflammatory response in which the intrinsic cytotoxic properties of T cells are upgraded with the properties of nanoparticles transfected into the T cells during the ex vivo expansion process. We report in vitro upgrading of human T cells using PEGylated boron carbide nanoparticles functionalised with a translocation peptide aimed at Boron Neutron Capture Therapy (BNCT). A key finding is that the metabolism of such upgraded human T cells were not affected by a payload of 0.13 pg boron per cell and that the nanoparticles were retained in the cell population after several cell divisions. This is vital for transporting nanoparticles by T cells to the tumor site.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Portadores de Fármacos
/
Linfocitos T
/
Inmunoterapia Adoptiva
/
Nanopartículas
Límite:
Humans
Idioma:
En
Revista:
J Nanosci Nanotechnol
Año:
2007
Tipo del documento:
Article
País de afiliación:
Dinamarca
Pais de publicación:
Estados Unidos