Development of conditioned place preference induced by intra-accumbens infusion of amphetamine is attenuated by co-infusion of dopamine D1 and D2 receptor antagonists.
Pharmacol Biochem Behav
; 89(3): 367-73, 2008 May.
Article
en En
| MEDLINE
| ID: mdl-18275994
The present study investigated the role of dopamine receptors within the nucleus accumbens in place conditioning induced by D-amphetamine. Previous work has shown that conditioned place preference can be established by intra-accumbens infusion of amphetamine. The present study further examined whether bilateral co-infusion of the selective dopamine receptor antagonists with D-amphetamine into this region would disrupt the development of conditioned place preference induced by intra-accumbens amphetamine treatment. Bilateral infusions of D-amphetamine into the nucleus accumbens at the dose of 10 microg per side significantly induced conditioned place preference. At the tested doses of 1 microg and 10 microg, either the selective D1 dopamine receptor antagonist (SCH23390) or the selective D2 dopamine receptor antagonist (raclopride) infused with the high dose into the nucleus accumbens significantly blocked the development of conditioned place preference induced by intra-accumbens amphetamine treatment. Furthermore, the sole infusion of SCH23390 or raclopride into the nucleus accumbens produced little or no place conditioning effect. It is concluded that the dopamine D1 and D2 receptors in the nucleus accumbens are critically involved in the development of amphetamine induced conditioned place preference.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Recompensa
/
Receptores de Dopamina D1
/
Antagonistas de Dopamina
/
Condicionamiento Psicológico
/
Antagonistas de los Receptores de Dopamina D2
/
Anfetamina
/
Núcleo Accumbens
Límite:
Animals
Idioma:
En
Revista:
Pharmacol Biochem Behav
Año:
2008
Tipo del documento:
Article
País de afiliación:
Taiwán
Pais de publicación:
Estados Unidos