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Genomewide linkage scan for combined obesity phenotypes using principal component analysis.
He, L-N; Liu, Y-J; Xiao, P; Zhang, L; Guo, Y; Yang, T-L; Zhao, L-J; Drees, B; Hamilton, J; Deng, H-Y; Recker, R R; Deng, H-W.
Afiliación
  • He LN; The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P R China.
Ann Hum Genet ; 72(Pt 3): 319-26, 2008 May.
Article en En | MEDLINE | ID: mdl-18261184
Traditional whole genome linkage scans for obesity were usually performed for a number of correlated obesity related phenotypes separately without considering their correlations. The purpose of this study was to identify quantitative trait loci (QTLs) underlying variations in multiple correlated obesity phenotypes. We performed principal component analysis (PCA) for four highly correlated obesity phenotypes (body mass index [BMI], fat mass, percentage of fat mass [PFM], and lean mass) in a sample of 427 pedigrees (comprising 3,273 individuals) and generated two independent principal components (PC1 and PC2). A whole genome linkage scan (WGS) was then conducted for PC1 and PC2. For PC1, the strongest linkage signal was identified on chromosome 20p12 (LOD = 2.67). For PC2, two suggestive linkages were found on 5q35 (LOD = 2.03) and 7p22 (LOD = 2.18). This study provided evidence supporting several previously identified linkage regions for obesity (e.g., 1p36, 6p23 and 7q34). In addition, our approach by linear combination of highly correlated obesity phenotypes identified several novel QTLs which were not found in genome linkage scans for individual phenotypes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Genoma Humano / Análisis de Componente Principal / Ligamiento Genético / Obesidad Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Ann Hum Genet Año: 2008 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Genoma Humano / Análisis de Componente Principal / Ligamiento Genético / Obesidad Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Ann Hum Genet Año: 2008 Tipo del documento: Article Pais de publicación: Reino Unido