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Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma.
Früh, M; Zhou, W; Zhai, R; Su, L; Heist, R S; Wain, J C; Nishioka, N S; Lynch, T J; Shepherd, F A; Christiani, D C; Liu, G.
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  • Früh M; Medical Oncology, Department of Medicine, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9.
Br J Cancer ; 98(4): 689-92, 2008 Feb 26.
Article en En | MEDLINE | ID: mdl-18253117
Helicobacter pylori (HP) infection appears protective against oesophageal adenocarcinoma (EA) risk. Matrix metalloproteinases (MMPs) are released in the presence of HP infection. In MMP2 wild-type individuals, HP was significantly protective of EA risk (adjusted odds ratio: 0.29; 95% confidence interval=0.1-0.7). Matrix metalloproteinases may modulate the EA-HP relationship.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Neoplasias Esofágicas / Adenocarcinoma / Helicobacter pylori / Infecciones por Helicobacter / Metaloproteinasa 2 de la Matriz Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Br J Cancer Año: 2008 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Neoplasias Esofágicas / Adenocarcinoma / Helicobacter pylori / Infecciones por Helicobacter / Metaloproteinasa 2 de la Matriz Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Br J Cancer Año: 2008 Tipo del documento: Article Pais de publicación: Reino Unido