alpha-Glucosidase inhibitors from the seeds of Syagrus romanzoffiana.
Phytochemistry
; 69(5): 1173-8, 2008 Mar.
Article
en En
| MEDLINE
| ID: mdl-18221760
Bioassay-guided fractionation against alpha-glucosidase resulted in isolation and characterization of eight active compounds from the EtOH extract of the seeds of Syagrus romanzoffiana. Of these, seven are stilbenoids, and two of them, 13-hydroxykompasinol A (1) and scirpusin C (4), possess potent inhibitory activity against alpha-glucosidase type IV from Bacillus stearothermophilus with the IC50 value of 6.5 and 4.9 microM, respectively. The in vivo assay on normal Wistar rats using oral sucrose challenge also demonstrated that kompasinol A (2) and 3,3',4,5,5'-pentahydroxy-trans-stilbene (5) possess significant effect in reducing the postprandial blood glucose level (10.2% and 12.1% at 10mg/kg, respectively). These results suggest that stilbenoids might be explored for their therapeutic potential as hypoglycemic agents.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estilbenos
/
Arecaceae
/
Inhibidores Enzimáticos
/
Inhibidores de Glicósido Hidrolasas
Límite:
Animals
Idioma:
En
Revista:
Phytochemistry
Año:
2008
Tipo del documento:
Article
Pais de publicación:
Reino Unido