Polyphenols, intracellular signalling and inflammation.
Ann Ist Super Sanita
; 43(4): 394-405, 2007.
Article
en En
| MEDLINE
| ID: mdl-18209273
Excessive inflammation is considered as a critical factor in many human diseases, including cancer, obesity, type II diabetes, cardiovascular diseases, neurodegenerative diseases and aging. Compounds derived from botanic sources, such as phenolic compounds, have shown anti-inflammatory activity in vitro and in vivo. Recent data suggest that polyphenols can work as modifiers of signal transduction pathways to elicit their beneficial effects. These natural compounds express anti-inflammatory activity by modulation of pro-inflammatory gene expression such as cyclooxygenase, lipoxygenase, nitric oxide synthases and several pivotal cytokines, mainly by acting through nuclear factor-kappa B and mitogen-activated protein kinase signalling. This review will discuss recent data on the control of inflammatory signalling exerted by some dietary polyphenols contained in Mediterranean diet. A clear understanding of the molecular mechanisms of action of phenolic compounds is crucial in the valuation of these potent molecules as potential prophylactic and therapeutic agents.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fenoles
/
Flavonoides
/
Transducción de Señal
/
Inflamación
/
Antiinflamatorios
/
Antioxidantes
Límite:
Humans
Idioma:
En
Revista:
Ann Ist Super Sanita
Año:
2007
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Italia