[Branched antimicrobial peptides].
Bioorg Khim
; 33(6): 588-92, 2007.
Article
en Ru
| MEDLINE
| ID: mdl-18173120
Branched peptides E(RLAR)2, E[E(RLAR)2]2, E(KLAR)2, and E[E(KLAR)2]2 were synthesized on the basis of tetrapeptides RLAR and KLAR and glutamic acid bis(pentafluorophenyl) ester. Their minimal antimicrobial concentrations were shown to decrease along with increase in branching, achieving 12 microM for Escherichia coli cells, which is comparable to antimicrobial activities of temporin, magainin, and dermaseptin. The branched peptides were found not to act on human erythrocytes.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oligopéptidos
/
Péptidos Catiónicos Antimicrobianos
/
Escherichia coli
Límite:
Humans
Idioma:
Ru
Revista:
Bioorg Khim
Año:
2007
Tipo del documento:
Article
Pais de publicación:
Rusia