Effect of metronidazole on surface properties of Bacteroides fragilis.

Cavalcanti, S M; Domingues, R M; Ferreira, M C; Costa e Silva Filho, F

Cavalcanti, S M; Domingues, R M; Ferreira, M C; Costa e Silva Filho, F.

Afiliación

Cavalcanti SM; Instituto de Microbiologia, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Brasil.

J Antimicrob Chemother ; 28(6): 819-26, 1991 Dec.

Article en En | MEDLINE | ID: mdl-1816180

RESUMEN

The effects of subinhibitory concentrations of metronidazole on the general morphology, ultrastructure and charge and hydrophobicity of Bacteroides fragilis were investigated using transmission and scanning electron microscopy, and measurements of zeta-potentials and contact angles. Metronidazole treatment induced morphological alterations in B. fragilis. Cells became filamentous and showed a significant loss of cytoplasm. The surface anionogenicity and hydrophobicity of B. fragilis were enhanced by the drug treatment. Metronidazole, by modifying B. fragilis surface properties, could alter, indirectly, interactions with host cells.

Asunto(s)

Bacteroides fragilis/efectos de los fármacos; Metronidazol/farmacología; Bacteroides fragilis/crecimiento & desarrollo; Bacteroides fragilis/ultraestructura; Pruebas de Sensibilidad Microbiana; Microscopía Electrónica; Microscopía Electrónica de Rastreo; Propiedades de Superficie/efectos de los fármacos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacteroides fragilis / Metronidazol Idioma: En Revista: J Antimicrob Chemother Año: 1991 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido

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