[Studies on bioassay-guided anti-inflammatory fraction in bark of Albizia julibrissin combined determination with LC-MS-MS].
Zhongguo Zhong Yao Za Zhi
; 32(19): 2021-5, 2007 Oct.
Article
en Zh
| MEDLINE
| ID: mdl-18161296
OBJECTIVE: To search the anti-inflammatory fraction of Albizia julibrissin. METHOD: Inflammatory model of Kunming mice ear edema induced by croton oil and determination combined with the LC-MS-MS-guided fractionation and isolation were used. RESULT: The n-butanol fraction (AJ-B) obtained from the ethanolic extract of the Cortex albiziae was the major active fraction. The lignan glycosides fraction (AJ-B-1), which was further isolated from AJ-B, showed significant anti-inflammatory activity and exhibited dose-dependent relationship in the dose of 5 to 20 mg x kg(-1). CONCLUSION: The method of bioassay-guided fractionation and isolation combined with the LC-MS-MS determination may be of benefit to the logical studies on the bioactive fractions or constituents of traditional Chinese materia medica.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Medicamentos Herbarios Chinos
/
Lignanos
/
Corteza de la Planta
/
Albizzia
/
Edema
/
Espectrometría de Masas en Tándem
Límite:
Animals
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Asunto de la revista:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Año:
2007
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
China