Valinomycin-induced modulation of adriamycin resistance and cationic probe distribution in MCF-7 cell lines.

Crifò, C; Capuozzo, E; Cucco, C; Zupi, G; Salerno, C

Crifò, C; Capuozzo, E; Cucco, C; Zupi, G; Salerno, C.

Afiliación

Crifò C; Department of Biochemical Sciences, University of Rome La Sapienza, Italy.

Biochem Int ; 25(4): 593-601, 1991 Nov.

Article en En | MEDLINE | ID: mdl-1815496

RESUMEN

In vitro restoration of adriamycin sensitivity in a resistant human breast tumor cell line was obtained by continuous exposure to nanomolar nontoxic valinomycin concentrations. Seven-day treatment with nanomolar valinomycin concentrations caused a slight increase of the signal of the cationic fluorescent cyanine probe DiOC5(3) but did not appreciably affect adriamycin incorporation in the cells. A marked increase of the DiOC5(3) signal was obtained in the presence of micromolar valinomycin concentrations, which were incompatible with the in vitro cellular growth.

Asunto(s)

Doxorrubicina/farmacología; Células Tumorales Cultivadas/efectos de los fármacos; Valinomicina/farmacología; Carbocianinas; División Celular/efectos de los fármacos; Doxorrubicina/administración & dosificación; Resistencia a Medicamentos; Sinergismo Farmacológico; Colorantes Fluorescentes; Humanos; Valinomicina/administración & dosificación

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Valinomicina / Células Tumorales Cultivadas / Doxorrubicina Límite: Humans Idioma: En Revista: Biochem Int Año: 1991 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Australia

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links