Clinico-biochemical study of experimental complicated cataracts.

Sihota, R; Mohan, M; Angra, S K; Mathur, R L

Sihota, R; Mohan, M; Angra, S K; Mathur, R L.

Afiliación

Sihota R; Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi.

Indian J Ophthalmol ; 39(4): 148-50, 1991.

Article en En | MEDLINE | ID: mdl-1810872

RESUMEN

Clinically observed complicated cataracts, generally do not have a definite causal factor. We studied the effects of E. coli toxin injected suprachoroidally, to simulate the effect of toxins released by extraocular organisms on the lens. 79.2% of eyes had a definable cataract at the end of the 6th week of observation. The biochemical changes portrayed an increased oxidative activity in the lens, evidenced by a fall in glutathione concentration, and the consequent tertiary reorientation of proteins to increase insoluble proteins, forming a cataract.

Asunto(s)

Catarata/metabolismo; Cristalino/metabolismo; Animales; Ácido Ascórbico/análisis; Cristalinas/análisis; Modelos Animales de Enfermedad; Endotoxinas; Escherichia coli; Lipopolisacáridos; Conejos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catarata / Cristalino Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Indian J Ophthalmol Año: 1991 Tipo del documento: Article Pais de publicación: India

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