Aqueous extract of the Helianthus annuus seed alleviates asthmatic symptoms in vivo.
Int J Mol Med
; 21(1): 57-61, 2008 Jan.
Article
en En
| MEDLINE
| ID: mdl-18097616
Molecular inflammation is a pivotal process in various degenerative immune diseases, including asthma and atopic dermatitis. In this study, we examined the effects of Helianthus annuus seed (HAS) aqueous extract on an in vivo anti-asthmatic model. Ovalbumin-induced mice were orally administered the aqueous extract of Helianthus annuus seeds, and their lungs were assessed by hematoxylin and eosin staining. Moreover, the expression levels of IL-4/IL-13 cytokines and IgE were determined. HAS extract induced a decrease in CD4+ cell number, IL-4/IL-13 expression, and IgE secretion levels in the lungs. Our findings collectively suggest that the HAS extract has considerable potential in reducing the asthma-like symptoms induced by a mouse ovalbumin challenge model. However, further isolation and purification of the extract is required to determine the specific factor(s) responsible for its anti-asthmatic activity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Asma
/
Semillas
/
Extractos Vegetales
/
Helianthus
/
Fitoterapia
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Int J Mol Med
Asunto de la revista:
BIOLOGIA MOLECULAR
/
GENETICA MEDICA
Año:
2008
Tipo del documento:
Article
Pais de publicación:
Grecia