Efficacy of sulforaphane is mediated by p38 MAP kinase and caspase-7 activations in ER-positive and COX-2-expressed human breast cancer cells.
Eur J Cancer Prev
; 16(6): 505-10, 2007 Dec.
Article
en En
| MEDLINE
| ID: mdl-18090122
Sulforaphane is an antioxidant and a potent stimulator of natural detoxifying enzyme and associated with lowered risk of cancer that is associated with the consumption of cruciferous vegetables. The chemopreventive effects of SFN was investigated using the MCF-7 human breast cancer cells and the M13SV1-immortalized human breast luminal epithelial cells. Sulforaphane reduced proliferation in MCF-7 cells and inhibited cyclooxygenase-2 expression in M13SV1 cells treated with 12-O-tetradecanoylphorbol-13-acetate (TPA). The chemopreventive effects of sulforaphane were associated with p38 mitogen-activated protein kinase suggest its important role in cell survival/apoptosis regulation and stabilization of cyclooxygenase-2. Sulforaphane upregulates p38 in MCF-7 cells and prevented TPA-reduced phosphorylation of p38 in M13SV1 cells, but activated caspase-7 associated with apoptosis in MCF-7 cells. These results suggest that sulforaphane may be an alternative candidate for targeted prevention of ER-positive and cyclooxygenase-2-induced phenotypes and breast cancer.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tiocianatos
/
Neoplasias de la Mama
/
Receptores de Estrógenos
/
Proteínas Quinasas p38 Activadas por Mitógenos
/
Ciclooxigenasa 2
/
Caspasa 7
Límite:
Humans
Idioma:
En
Revista:
Eur J Cancer Prev
Asunto de la revista:
NEOPLASIAS
/
SAUDE PUBLICA
Año:
2007
Tipo del documento:
Article
Pais de publicación:
Reino Unido