Systemic inflammation in chronic obstructive pulmonary disease: the role of exacerbations.
Proc Am Thorac Soc
; 4(8): 626-34, 2007 Dec.
Article
en En
| MEDLINE
| ID: mdl-18073394
The systemic manifestations of chronic obstructive pulmonary disease (COPD) exacerbations are recognized, but our understanding of their etiology and importance is lacking largely due to the small number of systematic and longitudinal studies. Most of the systemic manifestations are likely the result of inflammatory processes. Serum biomarkers, such as various cytokines, adipokines, C-reactive protein, and coagulation factors, are elevated during exacerbations. Our understanding of the systemic manifestations can be greatly enhanced if we integrate what is known about the basic science of systemic mediators with the translational science of their role in COPD exacerbations. Many overlapping connections and promising avenues of future research come to light with such a viewpoint.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad Pulmonar Obstructiva Crónica
/
Inflamación
Tipo de estudio:
Observational_studies
Límite:
Humans
Idioma:
En
Revista:
Proc Am Thorac Soc
Año:
2007
Tipo del documento:
Article
País de afiliación:
Países Bajos
Pais de publicación:
Estados Unidos