Psoralen plus ultraviolet A in the prophylactic treatment of benign summer light eruption.
Photodermatol Photoimmunol Photomed
; 8(3): 95-8, 1991 Jun.
Article
en En
| MEDLINE
| ID: mdl-1804294
We report the results of a French multicentre study to evaluate the efficiency of psoralen plus ultraviolet A (PUVA) therapy in the prophylactic treatment of benign summer light eruption (BSLE) and to establish the optimal protocol of radiation. Nine photobiology centres took part in this study; 83 patients (76 of them women) were evaluated. The radiation protocols were as follows: oral psoralen (8-methoxypsoralen; 0.6 mg/kg) was taken at each session; the starting dose of UVA radiation was determined according to skin type, with increments of 0.5 J/cm2 every 2 sessions. The subjects were randomized to receive 10-20 sessions 3 times per week. PUVA therapy was very effective: 68 patients (82%) reported total protection from BSLE. Four patients (5%) showed progress. Only 13% showed no improvement. The satisfactory results were not correlated with either the number of sessions or the J/cm2 of UVA. The intensity of tanning after the PUVA sessions did not appear to predict cure. Thirty-six percent of the patients had adverse reactions to treatment, including erythema, pruritus and triggering of BSLE. However, these effects only required the treatment to be stopped in 2% of the cases (for severe pruritus). The results in the various centres were similar.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastornos por Fotosensibilidad
/
Terapia PUVA
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Guideline
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Photodermatol Photoimmunol Photomed
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
DERMATOLOGIA
Año:
1991
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Reino Unido