Synthesis of thiadiazoles and 1,2,4-triazoles derived from cyclopropane dicarboxylic acid.

Sharba, A Hussain K; Al-Bayati, Rida H; Rezki, Nadjet; Aouad, Mohammed R

Sharba, A Hussain K; Al-Bayati, Rida H; Rezki, Nadjet; Aouad, Mohammed R.

Afiliación

Sharba AH; Department of Chemistry, College of Science, Al-Mustansirya University, Baghdad, Iraq. hussainirk@yahoo.com

Molecules ; 10(9): 1153-60, 2005 Sep 30.

Article en En | MEDLINE | ID: mdl-18007381

RESUMEN

New heterocyclic derivatives of cyclopropane dicarboxylic acid comprising thiadiazole and 1,2,4-triazole moieties are reported. Reaction of 1,1-cyclopropane dicarboxylic acid (1) with thiosemicarbazide and phosphorous oxychloride resulted in 1,1-bis (2-amino-1,3,4-thiadiazol-5- yl)cyclopropane (2). Cyclopropane dicarboxylic acid thiosemicarbazide (6) was converted into 1,1-bis(3-thio-4H-1,2,4-triazol-5-yl) cyclo- propane (7) by ring closure in an alkaline medium. The thiadiazole 2 and the triazole 7 were converted into a variety of derivatives.

Asunto(s)

Ácidos Carboxílicos/química; Ciclopropanos/química; Tiadiazoles/síntesis química; Triazoles/síntesis química; Ácidos Dicarboxílicos; Tiadiazoles/química; Triazoles/química

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiadiazoles / Triazoles / Ácidos Carboxílicos / Ciclopropanos Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2005 Tipo del documento: Article País de afiliación: Irak Pais de publicación: Suiza

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