Spectral clustering of fMRI data within regions of interest: clarification of L-dopa effects in Parkinson's disease.
Annu Int Conf IEEE Eng Med Biol Soc
; 2007: 5235-8, 2007.
Article
en En
| MEDLINE
| ID: mdl-18003188
Identifying active regions of the brain that are task-related is important in fMRI study. Current methods of determining functional Regions of Interest (ROIs) are unsatisfactory because they either reduce the effect size or bias the statistical results. We propose a spectral clustering method for assessing those voxels within an ROI that are suitable for further task-activation analysis. Different similarity functions are studied and the correlation index is chosen based on the simulation study. In real fMRI study, further group analysis employing regression is investigated to identify different brain activation patterns between groups in order to reveal the effects of disease and medicine. A real fMRI case study in Parkinson's disease suggests that the technique is promising, warranting further study.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Encéfalo
/
Mapeo Encefálico
/
Imagen por Resonancia Magnética
/
Levodopa
/
Análisis por Conglomerados
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Annu Int Conf IEEE Eng Med Biol Soc
Año:
2007
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación:
Estados Unidos