Oxidative damage and sensitivity to nociceptive stimulus and opioids in aging rats.
Neurobiol Aging
; 30(6): 910-9, 2009 Jun.
Article
en En
| MEDLINE
| ID: mdl-17997197
Oxidative stress contributes to aging and may cause alterations in pain and analgesia. Knowledge about effects of oxidative stress on the opioid system is very limited. This project was designed to determine the relationship between age-related oxidative damage and opioid antinociception. Three age groups of male Fischer 344 rats were tested for pain sensitivity and responses to morphine and fentanyl using the hot plate method. Oxidative stress markers in various brain regions were measured. With advancing age, nociceptive threshold and antinociceptive effects of opioids decreased significantly. There was a significant negative correlation between morphine antinociception and protein oxidation in cortex, striatum, and midbrain (r(2)=0.73, 0.87, and 0.77, respectively), and lipid peroxidation in cerebral cortex, hippocampus, and striatum (r(2)=0.73, 0.61, and 0.71, respectively). Similar correlation was observed between oxidative stress markers and fentanyl antinociception. These findings demonstrate that the age-related increase in oxidative damage in brain is associated with a significant decrease in the antinociceptive effects of opioids.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
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Envejecimiento
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Peroxidación de Lípido
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Especies Reactivas de Oxígeno
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Umbral del Dolor
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Estrés Oxidativo
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Analgésicos Opioides
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Neurobiol Aging
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos