[Prognostic significance of "sawtooth" PSA and "stepwise" PSA]. / PSA "en dents de scie" et PSA "en escalier": quelles implications pronostiques?
Prog Urol
; 17(5): 943-6, 2007 Sep.
Article
en Fr
| MEDLINE
| ID: mdl-17969793
OBJECTIVE: To evaluate the risk of diagnosing prostate cancer on repeated biopsies in patients with fluctuating PSA values compared to patients with stable or regularly increasing PSA values. MATERIAL: Retrospective study conducted on the 2000-2003 databases of 2 French teaching hospitals. Selected patients had a first negative prostatic biopsy, then at least one other series of prostatic biopsies. "Sawtooth" PSA was defined by a PSA value less than that of the previous assay. Other cases were described as "stepwise" PSA. RESULTS: 191 patients were included: 79 in the "sawtooth" group and 112 in the "stepwise" group. Prostate cancer was diagnosed in 53 patients (27.7%), on the second prostatic biopsy 39 cases. Prostate cancer was detected in 17 (21.5%) of the 79 patients of the "sawtooth" group. This proportion was not significantly different (p = 0.14) from that observed in patients of the "stepwise" group: 36/112 (32.1%). No significant difference in terms of age, stage, Gleason score and initial PSA was observed between patients with a diagnosis of prostate cancer in the "sawtooth" and "stepwise" groups. CONCLUSION: In our study, the risk of diagnosing prostate cancer on repeated prostatic biopsies was not greater in patients with "stepwise" PSA compared to patients with "sawtooth" PSA.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Antígeno Prostático Específico
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
/
Male
Idioma:
Fr
Revista:
Prog Urol
Asunto de la revista:
UROLOGIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Francia