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Uncontrolled headache induced by oxcarbazepine.
Piovesan, Elcio Juliato; Teive, Helio Ghizoni; de Paola, Luciano; Silvado, Carlos Eduardo; Crippa, Ana; Amaral, Vanise Campos Gomes; Della Colleta, Marcos Vinicius; Di Stani, Fabrizio; Werneck, Lineu Cesar.
Afiliación
  • Piovesan EJ; Headache Clinic, Neurology Service, Department of Internal Medicine, Hospital de Clínicas, Federal University of Paraná, Rua General Carneiro 181, 120 andar, sala 1236, CEP-80060-900, Curitiba-Paraná, Brazil. piovesan@avalon.sul.com.br
J Headache Pain ; 8(5): 301-5, 2007 Oct.
Article en En | MEDLINE | ID: mdl-17955169
Headache induced by acute exposure to a specific drug constitutes an idiosyncratic side effect. Metabolic imbalance appears as the leading aetiology, among several other hypotheses. Either primary headaches show a higher susceptibility to this idiosyncratic reaction or a drug-induced primary headache evolves in intensity and duration, becoming uncontrolled until the complete discontinuation of the drug in consideration. The goal of this study is to describe three patients diagnosed with migraine and epilepsy (both under control) who evolved into status migrainosus after the introduction of oxcarbazepine (OXC), as part of a switch off from carbamazepine (CBZ). Twenty-four to seventy-two hours following the switch, all patients developed intractable headache, despite the use of different symptomatic drugs. Complete recovery of the headache symptoms occurred only after OXC was discontinued. We discuss the potential mechanisms associated to OXC and status migrainosus, drug-induced headaches and uncontrolled headaches.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Carbamazepina / Neoplasias Neuroepiteliales / Trastornos de Cefalalgia / Epilepsia / Trastornos Migrañosos Tipo de estudio: Diagnostic_studies Límite: Adult / Female / Humans Idioma: En Revista: J Headache Pain Asunto de la revista: MEDICINA INTERNA / NEUROLOGIA / PSICOFISIOLOGIA Año: 2007 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Carbamazepina / Neoplasias Neuroepiteliales / Trastornos de Cefalalgia / Epilepsia / Trastornos Migrañosos Tipo de estudio: Diagnostic_studies Límite: Adult / Female / Humans Idioma: En Revista: J Headache Pain Asunto de la revista: MEDICINA INTERNA / NEUROLOGIA / PSICOFISIOLOGIA Año: 2007 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido