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Achievement of optimal average relative dose intensity and correlation with survival in diffuse large B-cell lymphoma patients treated with CHOP.
Bosly, A; Bron, D; Van Hoof, A; De Bock, R; Berneman, Z; Ferrant, A; Kaufman, L; Dauwe, M; Verhoef, G.
Afiliación
  • Bosly A; Department of Haematology, University Hospital of Mont-Godinne, Yvoir, Belgium. andre.bosly@sang.ucl.ac.be
Ann Hematol ; 87(4): 277-83, 2008 Apr.
Article en En | MEDLINE | ID: mdl-17952688
The treatment of diffuse large B-cell lymphoma with chemotherapy was retrospectively evaluated in 348 patients who had received at least three cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone)-like, ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, and prednisone)-like or CHVmP-BV (cyclophosphamide, hydroxorubicin, Vm-26, prednisone, vincristine and bleomycin) treatment in Belgium between 1995 and 2000. In our sample, the proportion who received each of the three regimens was 78.4, 16.4, and 5.2%, respectively. Of those prescribed CHOP-like regimens, 15% received <80% average relative dose intensity (ARDI). In 210 patients treated with CHOP-21 (77% of the CHOP-like group), median survival was 7.08 years in those who received >90% of the ARDI, significantly longer than in those who received < or = 90% of the ARDI (p = 0.002). Dose reductions and/or delays, mainly due to hematological toxicities, resulted in a reduction in treatment intensity. These data indicate that patient outcome is improved when the intensity of chemotherapy treatment is optimal.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Linfoma de Células B Grandes Difuso Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: Ann Hematol Asunto de la revista: HEMATOLOGIA Año: 2008 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Alemania
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Linfoma de Células B Grandes Difuso Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: Ann Hematol Asunto de la revista: HEMATOLOGIA Año: 2008 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Alemania