Use of intravitreal injection of triamcinolone acetonide in the treatment of age-related macular degeneration.
Indian J Ophthalmol
; 55(6): 431-5, 2007.
Article
en En
| MEDLINE
| ID: mdl-17951899
Age-related macular degeneration (AMD) is now considered an important and leading cause of blindness among elderly patients in developed and developing countries. AMD has two forms, dry and wet; both can lead to visual loss. However, occurrence of subfoveal choroidal neovascular (CNV) membrane in the wet form results in severe visual impairment. Treatment options for choroidal neovascularization are available in order to maintain and in some cases improve vision. Photodynamic therapy (PDT) has been used to treat both classic and occult membranes. It has known to cause choroidal hypoperfusion and production of vascular endothelial growth factor. Intravitreal steroid can possibly reduce the damage caused due to these undesirable effects. In the recent past, intravitreal injection of triamcinolone acetonide (IVTA) has been used extensively as an adjunct to PDT in AMD in order to reduce the number of PDT sessions and evaluate possible beneficial effects on vision. This article reviews the pharmacological attributes of triamcinolone, available evidence of its use as monotherapy or combination therapy to treat AMD, ocular side-effects thereof and ongoing clinical trials on IVTA.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Triamcinolona Acetonida
/
Glucocorticoides
/
Degeneración Macular
Límite:
Humans
Idioma:
En
Revista:
Indian J Ophthalmol
Año:
2007
Tipo del documento:
Article
País de afiliación:
India
Pais de publicación:
India