Detection sensitivity of MRI using ultra-small super paramagnetic iron oxide nano-particles (USPIO) in biological tissues.
Conf Proc IEEE Eng Med Biol Soc
; 2006: 5625-6, 2006.
Article
en En
| MEDLINE
| ID: mdl-17945909
Today, by injecting iron oxide based nanoparticles (USPIO) as MRI contrast agents, it is possible to study lymphatic system and some specific tumors and their metastasis. The type of surface coating, and coating characteristics of the nanoparticles are important factors for the biological properties of nanoparticles and their destination target. On the other hand, these properties contribute to different signal intensities. This may confine application of all types of USPIO based contrast agents in routine daily experiments. In this study, the ability of detecting these particles having various sizes and coating properties was evaluated for MRI applications. Signal intensity changes after administration of these particles into tissues have been studied and their detection sensitivity was evaluated using a liver phantom and animal model (rat). IO based nanoparticles of various sizes (8-30 nm) functionalized and coated with various surface polymers such as dextran and starch, amine and hydroxide groups, and bear IO particles were used to investigate the signal changes. The optimized pulse sequences for proper demonstration of lymph nodes using these contrast agents were found (T2* FSPGR protocol with fat suppressions). A detection sensitivity of 98% was achieved in most experiments during applying a proper MR protocol. However, the type of surface coating, and coating characteristics such as thickness were shown to be essential factors for MRI signal intensity in both T1 and T2 protocols.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Imagen por Resonancia Magnética
/
Compuestos Férricos
/
Nanopartículas del Metal
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Conf Proc IEEE Eng Med Biol Soc
Asunto de la revista:
ENGENHARIA BIOMEDICA
Año:
2006
Tipo del documento:
Article
Pais de publicación:
Estados Unidos