Morphogenic signaling in neurons via neurotransmitter receptors and small GTPases.
Mol Neurobiol
; 35(3): 278-87, 2007 Jun.
Article
en En
| MEDLINE
| ID: mdl-17917116
Several neurotransmitters including serotonin and glutamate have been shown to be involved in many aspects of neural development, such as neurite outgrowth, regulation of neuronal morphology, growth cone motility and dendritic spine shape and density, in addition to their well-established role in neuronal communication. This review focuses on recent advances in our understanding of the molecular mechanisms underlying neurotransmitter-induced changes in neuronal morphology. In the first part of the review, we introduce the roles of small GTPases of the Rho family in morphogenic signaling in neurons and discuss signaling pathways, which may link serotonin, operating as a soluble guidance factor, and the Rho GTPase machinery, controlling neuronal morphology and motility. In the second part of the review, we focus on glutamate-induced neuroplasticity and discuss the evidence on involvement of Rho and Ras GTPases in functional and structural synaptic plasticity triggered by the activation of glutamate receptors.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Receptores de Serotonina
/
Receptores de N-Metil-D-Aspartato
/
Proteínas de Unión al GTP rho
/
Proteínas Activadoras de ras GTPasa
/
Forma de la Célula
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Mol Neurobiol
Asunto de la revista:
BIOLOGIA MOLECULAR
/
NEUROLOGIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Estados Unidos