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High nerve growth factor receptor (p75NTR) expression is a favourable prognostic factor in paediatric B cell precursor-acute lymphoblastic leukaemia.
Troeger, Anja; Gudowius, Sonja; Escherich, Gabriele; den Boer, Monique L; Glouchkova, Ludmila; Ackermann, Birgit; Meisel, Roland; Laws, Hans-Juergen; Groeger, Marketa; Wessalowski, Ruediger; Willers, Reinhart; Harbott, Jochen; Pieters, Rob; Goebel, Ulrich; Janka-Schaub, Gritta E; Hanenberg, Helmut; Dilloo, Dagmar.
Afiliación
  • Troeger A; Clinic for Paediatric Haematology, Oncology and Immunology, Heinrich Heine University, Duesseldorf, Germany. troeger@med.uni-duesseldorf.de
Br J Haematol ; 139(3): 450-7, 2007 Nov.
Article en En | MEDLINE | ID: mdl-17910636
Nerve growth factor (NGF) plays a pivotal role in cellular survival/death decisions with the low affinity receptor p75NTR predominately transmitting anti-proliferative signals. In spite of its established role in B-cell function and identification as a prognostically favourable marker in a number of malignancies, little is known about the expression pattern and prognostic significance of p75NTR in B cell precursor-acute lymphoblastic leukaemia (BCP-ALL). p75NTR expression was prospectively studied on primary ALL-blasts in a cohort of paediatric patients with common ALL (n = 86) and preB-ALL (n = 34) treated within the Co-operative study group for childhood acute lymphoblastic leukaemia (CoALL) protocol, CoALL06-97. Flow cytometric analysis showed that almost half of the patients expressed no or negligible amounts of p75NTR (<10%). The median expression in patients expressing p75NTR beyond that threshold was 49% (range 11-100%). In patients classified as low-risk at diagnosis, p75NTR expression was significantly higher than in high-risk patients (P = 0.001). Of note, p75NTR expression was lower in the 21 patients who subsequently developed relapse compared with those remaining in remission (P = 0.038). Accordingly, relapse-free survival was significantly better in patients expressing high surface p75NTR (P = 0.041). Thus, in this prospective analysis, high p75NTR expression was a strong prognostic marker that identified a group of paediatric ALL patients with favourable outcome.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras B / Biomarcadores de Tumor / Receptores de Factor de Crecimiento Nervioso / Proteínas del Tejido Nervioso Tipo de estudio: Clinical_trials / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Br J Haematol Año: 2007 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Buscar en Google
Añadir a Mi BVS
Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras B / Biomarcadores de Tumor / Receptores de Factor de Crecimiento Nervioso / Proteínas del Tejido Nervioso Tipo de estudio: Clinical_trials / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Br J Haematol Año: 2007 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido