Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief.
Clin Pharmacol Ther
; 83(4): 559-66, 2008 Apr.
Article
en En
| MEDLINE
| ID: mdl-17898703
The pharmacokinetics and pharmacodynamics of morphine are under the control of several polymorphic genes, which can account for part of the observed interindividual variation in pain relief. We focused on two such genes: ABCB1/MDR1, a major determinant of morphine bioavailability, and OPRM1, which encodes for the mu-opioid receptor, the primary site of action for morphine. One hundred and forty-five patients of Italian origin undergoing morphine therapy were genotyped for the single-nucleotide polymorphism (SNP) C3435T of ABCB1/MDR1 and for the A80G SNP of OPRM1. Pain relief variability was significantly (P<0.0001) associated with both polymorphisms. Combining the extreme genotypes of both genes, the association between patient polymorphism and pain relief improved (P<0.00001), allowing the detection of three groups: strong responders, responders, and non-responders, with sensitivity close to 100% and specificity more than 70%. This study provides a good example of the possible clinical use of pharmacogenetics.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dolor
/
Receptores Opioides mu
/
Miembro 1 de la Subfamilia B de Casetes de Unión a ATP
/
Polimorfismo de Nucleótido Simple
/
Población Blanca
/
Analgésicos Opioides
/
Morfina
Tipo de estudio:
Diagnostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Clin Pharmacol Ther
Año:
2008
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Estados Unidos