166Holmium-containing glass for internal radiotherapy of tumors.

Brown, R F; Lindesmith, L C; Day, D E

Brown, R F; Lindesmith, L C; Day, D E.

Afiliación

Brown RF; Department of Life Sciences, University of Missouri-Rolla 65401.

Int J Rad Appl Instrum B ; 18(7): 783-90, 1991.

Article en En | MEDLINE | ID: mdl-1787088

RESUMEN

Aluminosilicate glass containing the beta-emitter 166Ho was tested for tumor cell killing effectiveness with the BT-20 human mammary carcinoma cell line as a model. Incubation of BT-20 cells with 166Ho glass partially inhibited DNA replication and completely blocked growth in cells located within 1.0 mm of the radioactive fiber. Growth of BT-20 tumor xenografts in nude mice was dramatically inhibited by injection of 2-5 microns fragments of 166Ho glass (200 microCi/tumor). The results suggest that 166Ho glass would be an effective modality for deposition of intense beta- radiation for localized internal radiotherapy of tumors.

Asunto(s)

Neoplasias de la Mama/radioterapia; Holmio/uso terapéutico; Radioisótopos/uso terapéutico; Animales; Braquiterapia; Supervivencia Celular/efectos de la radiación; ADN/metabolismo; Vidrio; Humanos; Ratones; Ratones Endogámicos BALB C; Ratones Desnudos; Trasplante de Neoplasias; Células Tumorales Cultivadas

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radioisótopos / Neoplasias de la Mama / Holmio Límite: Animals / Humans Idioma: En Revista: Int J Rad Appl Instrum B Asunto de la revista: BIOLOGIA / MEDICINA NUCLEAR Año: 1991 Tipo del documento: Article Pais de publicación: Reino Unido

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