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Association of amino-terminal propeptide of type III procollagen and acute myocardial rejection in male patients receiving heart transplantation.
Lin, Yen-Hung; Liu, Chung-Pin; Hsu, Ron-Bin; Lee, Chi-Ming; Wang, Shoei-Shen; Kao, Hsien-Li; Chao, Chia-Lun; Shiau, Yu-Chien; Hung, Chi-Sheng; Liao, Lin-Chu; Ho, Yi-Lwun.
Afiliación
  • Lin YH; Department of Internal Medicine, Division of Cardiology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Clin Chem Lab Med ; 45(8): 1004-8, 2007.
Article en En | MEDLINE | ID: mdl-17867989
BACKGROUND: The amino-terminal propeptides of type I and III procollagens (PINP and PIIINP) are markers reflecting the status of collagen turnover. We hypothesized that measurement of these serum procollagen propeptides could be used to non-invasively assess acute rejection in heart transplant recipients. METHODS: In heart transplant recipients, endomyocardial biopsy specimens taken at 6 and 12 months after surgery were used for study. PINP and PIIINP were measured postoperatively at 3, 6, and 12 months. RESULTS: A total of 20 male heart transplant patients and seven male control subjects were enrolled. Five patients showed rejection 6 months after transplantation (group 1), while 15 patients showed no rejection (group 2). In group 2 patients, serum PINP and PIIINP levels decreased significantly 6 months after transplantation. In contrast, elevation of serum PINP and PIIINP levels persisted in group 1 patients 6 months after transplantation. At 6 months after transplantation, group 1 patients had significantly higher PIIINP levels than group 2 patients (p=0.025) and controls (p=0.003). After immunosuppressive therapy, all group 1 patients were free of rejection 12 months after transplantation and serial serum PIIINP levels decreased significantly in these patients. CONCLUSIONS: Serum PIIINP levels represent a non-invasive method to reflect the occurrence and resolution of acute rejection.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Valor Predictivo de las Pruebas / Trasplante de Corazón / Procolágeno / Rechazo de Injerto Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: Clin Chem Lab Med Asunto de la revista: QUIMICA CLINICA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2007 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Alemania
Buscar en Google
Añadir a Mi BVS
Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Valor Predictivo de las Pruebas / Trasplante de Corazón / Procolágeno / Rechazo de Injerto Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: Clin Chem Lab Med Asunto de la revista: QUIMICA CLINICA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2007 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Alemania