[IgG-kappa type multiple myeloma with cytoplasmic crystalline inclusions].
Rinsho Ketsueki
; 48(8): 652-8, 2007 Aug.
Article
en Ja
| MEDLINE
| ID: mdl-17867303
An 82-year-old male was admitted to our hospital because of anemia with Hb 6.9/dl. The serum monoclonal IgG of the kappa type was detected. Bone marrow aspiration showed the presence of 38.9% atypical plasma cells with crystalline inclusions. These crystalline inclusions were stained with acid phosphatase, and remained unstained with MPO, PAS and Congo-Red staining. Immunofluorescence studies showed the plasma cells were positive for IgG-kappa type immunoglobulin and CD138. Electron microscopy revealed varying numbers of stick-like, rod-shaped, rhomboid or rectangular crystals of a variety of lengths and sizes with a periodicity giving an appearance of longitudinal striation. The inclusions were most often surrounded by ribosomes. Some crystalline inclusions were located in the rough-surfaced endoplasmic reticulum. Their presence was probably due to an abnormality in the synthesis and/or secretion of immunoglobulin.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inmunoglobulina G
/
Cuerpos de Inclusión
/
Cadenas kappa de Inmunoglobulina
/
Mieloma Múltiple
Tipo de estudio:
Diagnostic_studies
Límite:
Aged80
/
Humans
/
Male
Idioma:
Ja
Revista:
Rinsho Ketsueki
Año:
2007
Tipo del documento:
Article
Pais de publicación:
Japón