Sex comparison of heme pathway in rats bearing hepatic tumors.
Tumori
; 77(5): 379-84, 1991 Oct 31.
Article
en En
| MEDLINE
| ID: mdl-1781034
The present study was undertaken to explore the effect of the presence of hepatic tumors induced by diethylinitrosamine (DENA) on the metabolic heme pathway, and to assess whether these tumors can modify the response of rats to the porphyrinogenic drug hexachlorobenzene (HCB) and whether the above mentioned effects occur to a greater extent in females than males. The results obtained showed that: a) Females were more susceptible to the hepatocarcinogenicity of DENA than males. b) Female normal and DENA treated rats were more susceptible than male rats to the porphyrinogenicity of HCB. c) The presence of hepatic DENA induced tumors could diminish basal hepatic ferrochelatase activity. d) Hepatic tumors could modify the response of animals to a porphyrinogenic drug such as HCB. Thus, both female and male DENA/HBC rats accumulated more porphyrins and showed a lower delta-aminolevulinate synthase and uroporphyrinogen I synthase induction than HCB rats. e) The heme pathway was functional in DENA induced tumors in both male and female rats but they were little affected by HCB.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Porfirias
/
Porfirinas
/
Caracteres Sexuales
/
Hemo
/
Neoplasias Hepáticas Experimentales
Límite:
Animals
Idioma:
En
Revista:
Tumori
Año:
1991
Tipo del documento:
Article
País de afiliación:
Argentina
Pais de publicación:
Estados Unidos