Ultrastructural pathological changes in mice kidney caused by Plasmodium berghei infection.
J Submicrosc Cytol Pathol
; 38(2-3): 143-8, 2006.
Article
en En
| MEDLINE
| ID: mdl-17784642
Malaria, a common health problem in certain parts of the world, has a considerable morbidity and mortality. This work reports under electron microscopy studies serious ultrastructural kidney damage such as extensive cytoplasmic vacuolation, vesiculation and autophagic vacuoles in proximal tubular cells. A thickened endothelial wall on peritubular capillary, interdigitation disorganization and significant decrease of their number in some areas were detected. Swollen rough endoplasmic reticulum, swollen mitochondria, and parasitized erythrocytes were observed. Many epithelial cells exhibited cytoplasmic areas of autophagia and a myelin-like form. A tubular cell presented severe cytoarchitecture alterations. Abundant lipid droplets were noticed. Almost total loss of interdigitations, rough endoplasmic reticulum vesiculation, peritubular capillaries with endothelial cells thickened cytoplasm, papillary processes projected to the lumen, and an inflammatory infiltrate of macrophages were also observed. These ultrastructural kidney changes could cause, on the basis of their clinical and pathologic expressions, a fat accumulation, an acute temporary reversible glomerulonephritis, a chronic progressive irreversible glomerulonephritis, and an acute renal failure (ARF).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plasmodium berghei
/
Microscopía Electrónica de Transmisión
/
Riñón
/
Glomérulos Renales
/
Túbulos Renales Proximales
/
Malaria
Límite:
Animals
Idioma:
En
Revista:
J Submicrosc Cytol Pathol
Asunto de la revista:
PATOLOGIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Venezuela
Pais de publicación:
Italia