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An in vivo study of the host tissue response to subcutaneous implantation of PLGA- and/or porcine small intestinal submucosa-based scaffolds.
Kim, Moon Suk; Ahn, Hyun Hee; Shin, Yu Na; Cho, Mi Hee; Khang, Gilson; Lee, Hai Bang.
Afiliación
  • Kim MS; Fusion Biotechnology Research Center, Korea Research Institute of Chemical Technology, P.O. Box 107, Yuseong, Daejeon 305-600, Republic of Korea.
Biomaterials ; 28(34): 5137-43, 2007 Dec.
Article en En | MEDLINE | ID: mdl-17764737
An innate immune response is often found at the site of biomaterial implantation. Since the effective use of biomaterials in vivo requires good biocompatibility and biofunctionality, it is vital that we assess and compare the inflammatory reactions provoked by various implanted biomaterials in vivo. In the present study, we assessed the host tissue response to poly(lactic-co-glycolic acid) (PLGA)- and small intestinal submucosa (SIS)-based scaffolds subcutaneously implanted in Fischer rats. Our results revealed that the PLGA-based scaffolds resulted in severe post-implantation inflammation, whereas the SIS-based scaffolds induced only a slight post-implantation inflammation and a PLGA/SIS-based copolymer yielded intermediate results.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Poliglicólico / Materiales Biocompatibles / Ácido Láctico / Ingeniería de Tejidos / Mucosa Intestinal / Intestino Delgado Límite: Animals Idioma: En Revista: Biomaterials Año: 2007 Tipo del documento: Article Pais de publicación: Países Bajos
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Poliglicólico / Materiales Biocompatibles / Ácido Láctico / Ingeniería de Tejidos / Mucosa Intestinal / Intestino Delgado Límite: Animals Idioma: En Revista: Biomaterials Año: 2007 Tipo del documento: Article Pais de publicación: Países Bajos