Verbal memory and plasma drug concentrations in elderly depressives treated with nortriptyline.

Young, R C; Mattis, S; Alexopoulos, G S; Meyers, B S; Shindledecker, R D; Dhar, A K

Young, R C; Mattis, S; Alexopoulos, G S; Meyers, B S; Shindledecker, R D; Dhar, A K.

Afiliación

Young RC; Cornell University Medical College, New York, NY.

Psychopharmacol Bull ; 27(3): 291-4, 1991.

Article en En | MEDLINE | ID: mdl-1775601

RESUMEN

Performance on a verbal memory task and affective state were assessed in geriatric major depressives before and during 6 weeks of treatment with nortriptyline (NT) in a fixed-dose design study. Higher plasma NT concentration was associated with poorer free recall but better affective outcome. In contrast, higher plasma Z-10-hydroxynortriptyline (Z-10-OH-NT) concentration was associated with more efficient free recall. Concentration-effect relationships were noted in patients later classified as cognitively unimpaired using the Dementia Rating Scale after optimal treatment, rather than in those with residual cognitive impairment.

Asunto(s)

Trastorno Depresivo/psicología; Memoria/efectos de los fármacos; Nortriptilina/uso terapéutico; Anciano; Anciano de 80 o más Años; Trastorno Depresivo/sangre; Trastorno Depresivo/tratamiento farmacológico; Femenino; Humanos; Masculino; Nortriptilina/sangre; Escalas de Valoración Psiquiátrica

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Depresivo / Memoria / Nortriptilina Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Psychopharmacol Bull Año: 1991 Tipo del documento: Article Pais de publicación: Estados Unidos

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