Effects of substance abuse on ventricular and sulcal measures assessed by computerised tomography.
Br J Psychiatry
; 159: 217-21, 1991 Aug.
Article
en En
| MEDLINE
| ID: mdl-1773237
Computerised tomography (CT) was used to assess the possible effects of substance abuse on brain morphology. Polydrug abusers had significantly wider third ventricles than normal controls, with a positive correlation between age and ventricle:brain ratio (VBR). Assuming no effect of age, estimated quantity of substance abuse was not significantly related to ventricular and sulcal measures, except that alcohol consumption correlated positively with VBR and severity of cocaine use correlated negatively with sulcal width. When age of the subjects was partialled out, alcohol use showed a tendency for association with VBR; however, severity of cocaine use did not remain a significant predictor of cortical sulcal width. The findings suggest that chronic use of alcohol, but not necessarily of other commonly abused substances, produces brain atrophy.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Psicotrópicos
/
Encéfalo
/
Tomografía Computarizada por Rayos X
/
Ventrículos Cerebrales
/
Trastornos Relacionados con Sustancias
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Br J Psychiatry
Año:
1991
Tipo del documento:
Article
Pais de publicación:
Reino Unido