Methylphenidate-induced changes in cerebral hemodynamics measured by functional near-infrared spectroscopy.
J Child Neurol
; 22(7): 812-7, 2007 Jul.
Article
en En
| MEDLINE
| ID: mdl-17715271
The aim of the present preliminary study was to evaluate the feasibility of measuring cerebral hemodynamic effects of a clinical dose of methylphenidate by near-infrared spectroscopy in 10 boys (median age, 10.7 years; range, 8.6-11.8 years) with developmental attention-deficit/hyperactivity disorder (ADHD). Using a Trail Making Test known to activate the left dorsolateral prefrontal cortex, cerebral hemodynamic changes show a lower increase of cerebral blood volume in the right prefrontal cortex (P = .033) and a lower increase of the tissue oxygenation index in the left prefrontal cortex (P = .015) in the condition after intake of methylphenidate compared with a drug-naive situation. A lower increase of the tissue oxygenation index indicates a changing regional oxygen metabolism and consumption induced by methylphenidate. Near-infrared spectroscopy is a sensitive tool for measuring pharmacological effects of methylphenidate on the cerebral hemodynamics.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Atención
/
Trastorno por Déficit de Atención con Hiperactividad
/
Circulación Cerebrovascular
/
Corteza Prefrontal
/
Estimulantes del Sistema Nervioso Central
/
Metilfenidato
Límite:
Child
/
Humans
/
Male
Idioma:
En
Revista:
J Child Neurol
Asunto de la revista:
NEUROLOGIA
/
PEDIATRIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Suiza
Pais de publicación:
Estados Unidos