Effects of MK-801 stereoisomers on schedule-controlled behavior in rats.
Psychopharmacology (Berl)
; 105(4): 477-80, 1991.
Article
en En
| MEDLINE
| ID: mdl-1771215
Behavioral effects of (+)MK-801 (0.03-0.32 mg/kg) and (-)MK-801 (0.32-3.20 mg/kg) were evaluated in rats using a multiple fixed-ratio, fixed-interval (FR20, FI2) schedule of food presentation. Both enantiomers produced dose-dependent decreases in response rate under the FR20 and in this respect (+)MK-801 was approximately ten times as potent as (-)MK-801. Under the FI2 schedule component, the (+) enantiomer produced substantial increases as well as decreases in response rate whereas the (-) enantiomer produced only decreases. When 0.178 mg/kg (+)MK-801 and 1.78 mg/kg (-)MK-801 were administered for 11 consecutive days, tolerance developed to the decrease in response rate under the FR20 schedule component. Tolerance to the effects of the (+) enantiomer under the FI2 schedule component was indicated by progressively larger increases in response rate than those observed during acute administration. These results support potential therapeutic applications of MK-801.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Conducta Animal
/
Maleato de Dizocilpina
Límite:
Animals
Idioma:
En
Revista:
Psychopharmacology (Berl)
Año:
1991
Tipo del documento:
Article
Pais de publicación:
Alemania