Incidence of axillary recurrence in 344 sentinel node negative breast cancer patients after intermediate follow-up. A prospective study into the accuracy of sentinel node biopsy in breast cancer patients.

Heuts, E M; van der Ent, F W C; Hulsewé, K W E; Heeren, P A M; Hoofwijk, A G M

Heuts, E M; van der Ent, F W C; Hulsewé, K W E; Heeren, P A M; Hoofwijk, A G M.

Afiliación

Heuts EM; Department of general surgery and surgical oncology, Maaslandziekenhuis, Sittard, the Netherlands. e.heuts@orbisconcern.nl

Acta Chir Belg ; 107(3): 279-83, 2007 Jun.

Article en En | MEDLINE | ID: mdl-17685253

RESUMEN

Sentinel lymph node biopsy (SLNB) has been validated in the treatment of breast carcinoma and is considered to stage the axilla adequately in this disease. However, long-term follow-up data are scarce. We evaluated the results of SLNB with respect to loco-regional failures in the axilla in SN-negative patients with invasive breast carcinoma and analysed their causal factors. Between 1997 and May 2004, 656 patients without clinically palpable lymph nodes were included in our study. Data with regard to demographics, diagnostics, therapy and follow up were gathered prospectively from all patients. Patients treated after May 2004 were excluded from this study to permit at least one year of follow-up. Out of the 656 patients, 344 patients with a negative sentinel lymph node biopsy did not undergo axillary dissection and were followed up clinically. Median follow up was 43 months. In 3 patients (0.9%) axillary recurrences developed. All three patients subsequently underwent a completion axillary dissection, chemotherapy and radiotherapy. The low rate of clinical axillary recurrence after an intermediate follow up period suggests that a negative SN biopsy accurately reflects the nodal stage in patients with breast cancer.

Asunto(s)

Neoplasias de la Mama/patología; Carcinoma Ductal de Mama/patología; Carcinoma Lobular/patología; Metástasis Linfática/patología; Recurrencia Local de Neoplasia/patología; Biopsia del Ganglio Linfático Centinela; Adulto; Anciano; Axila; Neoplasias de la Mama/tratamiento farmacológico; Neoplasias de la Mama/radioterapia; Neoplasias de la Mama/cirugía; Carcinoma Ductal de Mama/tratamiento farmacológico; Carcinoma Ductal de Mama/radioterapia; Carcinoma Ductal de Mama/cirugía; Carcinoma Lobular/tratamiento farmacológico; Carcinoma Lobular/radioterapia; Carcinoma Lobular/cirugía; Quimioterapia Adyuvante; Terapia Combinada; Femenino; Estudios de Seguimiento; Humanos; Escisión del Ganglio Linfático; Mastectomía Segmentaria; Persona de Mediana Edad; Recurrencia Local de Neoplasia/cirugía; Países Bajos; Guías de Práctica Clínica como Asunto; Estudios Prospectivos; Radioterapia Adyuvante; Reoperación

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Carcinoma Lobular / Carcinoma Ductal de Mama / Biopsia del Ganglio Linfático Centinela / Metástasis Linfática / Recurrencia Local de Neoplasia Tipo de estudio: Guideline / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged País/Región como asunto: Europa Idioma: En Revista: Acta Chir Belg Año: 2007 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido

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