The time-dependent block of NMDA glutamate receptor influences hippocampal LTP in inborn cerebellar degeneration mouse model.
Prague Med Rep
; 108(1): 29-36, 2007.
Article
en En
| MEDLINE
| ID: mdl-17682724
The effect of single dose of NMDA glutamate receptor blockage administration on the hippocampal LTP was evaluated in animal model of inborn cerebellar degeneration. We compared the level of possible LTP blockade in two groups of animals, Lurcher mutant mice and their healthy littermates which served as controls. In the second part of the study we tested group of mice which were influenced repeatedly by the same NMDA blocker (MK-801) during behavioral experiments. Our results suggest a similar effect of blockade either after single or chronic MK-801 administration; both of them practically disrupted LTP generation with differences between healthy and neurodegenerative animals.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Atrofias Olivopontocerebelosas
/
Receptores de N-Metil-D-Aspartato
/
Potenciación a Largo Plazo
/
Hipocampo
Límite:
Animals
Idioma:
En
Revista:
Prague Med Rep
Asunto de la revista:
MEDICINA
Año:
2007
Tipo del documento:
Article
País de afiliación:
República Checa
Pais de publicación:
República Checa