High frequency of amantadine-resistant influenza A (H3N2) viruses in the 2005-2006 season and rapid detection of amantadine-resistant influenza A (H3N2) viruses by MAMA-PCR.
Jpn J Infect Dis
; 60(4): 202-4, 2007 Jul.
Article
en En
| MEDLINE
| ID: mdl-17642534
Using the newly designed mismatch amplification mutation assay (MAMA) PCR, we demonstrated the high frequency of amantadine-resistant influenza A (H3N2) viruses isolated during the 2005-2006 season by detecting the mutation at amino acid position 31 of the M2 protein (S31N). Further, phylogenetic analyses of the HA1 sequences of the S31N viruses revealed that they comprised a clonal lineage that would result in the common characteristic amino acid changes at positions 193 (Ser to Phe) and 225 (Asp to Asn) of the HA protein. We also demonstrated that the S31N/S193F/D225N viruses had already emerged in Aichi Prefecture by the end of the previous 2004-2005 season.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Amantadina
/
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
/
Gripe Humana
/
Subtipo H3N2 del Virus de la Influenza A
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Jpn J Infect Dis
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
Año:
2007
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Japón