The alpha-tocopherol transfer protein.
Vitam Horm
; 76: 45-65, 2007.
Article
en En
| MEDLINE
| ID: mdl-17628171
Almost a century ago, plant extracts were documented to be critical for the fertility of rodents. This activity was later ascribed to vitamin E, a term comprising a number of structurally related plant lipids that function as fat soluble antioxidants. The alpha-tocopherol transfer protein (TTP) is a critical regulator of vitamin E status that stimulates the movement of vitamin E between membrane vesicles in vitro and facilitates the secretion of tocopherol from hepatocytes. Heritable mutations in the ttpA gene cause ataxia with vitamin E deficiency (AVED), an autosomal recessive disorder characterized by low plasma vitamin E levels and progressive neurodegeneration. This chapter summarizes recent advances in our understanding of the molecular and physiological aspects of TTP activity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vitamina E
/
Proteínas Portadoras
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Vitam Horm
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos