Making sense of muscle fatigue and liver lesions.
Z Gastroenterol
; 45(7): 609-11, 2007 Jul.
Article
en En
| MEDLINE
| ID: mdl-17620225
Muscle weakness is a common complaint in clinical practice. If this symptom is combined with focal liver lesions there is a broad spectrum of differential diagnoses for the gastroenterologist to consider. Tumors of neuroendocrine origin such as small-cell lung carcinoma (SCLC) produce a wide array of peptide hormones and are common causes of paraneoplastic syndromes. We report on a 68-year-old woman who presented with progressing muscle fatigue and multiple liver lesions on ultrasonography. Hypertension, hyperglycemia, hypokalemia and metabolic alkalosis prompted consideration of underlying hypercortisolism. Further work-up demonstrated an acute ectopic ACTH syndrome as paraneoplastic manifestation of a small cell lung carcinoma. The woman deteriorated rapidly and finally died from intracranial tumor spread and septic complications. This case stresses the diagnostic and therapeutic difficulties of acute ectopic ACTH syndrome in the setting of SCLC.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síndromes Paraneoplásicos
/
Síndrome de ACTH Ectópico
/
Tomografía Computarizada por Rayos X
/
Carcinoma de Células Pequeñas
/
Debilidad Muscular
/
Neoplasias Hepáticas
/
Neoplasias Pulmonares
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
Idioma:
En
Revista:
Z Gastroenterol
Año:
2007
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Alemania