Ultrastructural signs of altered intracellular metabolism in acral persistent papular mucinosis.
J Cutan Pathol
; 18(5): 347-52, 1991 Oct.
Article
en En
| MEDLINE
| ID: mdl-1761787
An asymptomatic 24-year-old woman presented with multiple discrete papules on the extensor surfaces of the hands and wrists. Light microscopy revealed focal increase in the amount of dermal fibroblasts as well as deposition of hyaluronidase-labile mucoid substance. The collagen and elastin were decreased. The changes were consistent with acral persistent papular mucinosis (APPM). In electron microscopy, the intercellular glycosaminoglycans showed small ruthenium red-positive granules and thin filaments indicating normal morphology. The fibroblastic cells, however, were conspicuously altered. Endoplasmic reticulum was dilated, cytoplasm contained large amounts of osmiophilic, concentric lysosomal structures, and there was distinct fibrous lamina in the nuclear membrane. It was concluded that the primary event in APPM probably affects the intracellular metabolism of the dermal fibroblast. The accumulation of lysosomal structures may be a distinct feature of APPM differentiating it from the other reactive cutaneous mucinoses, or it may only reflect nonspecific degeneration in a long-standing lesion.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dermatosis de la Mano
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
J Cutan Pathol
Año:
1991
Tipo del documento:
Article
País de afiliación:
Finlandia
Pais de publicación:
Estados Unidos