Characterization and functions of beta defensins in the epididymis.
Asian J Androl
; 9(4): 453-62, 2007 Jul.
Article
en En
| MEDLINE
| ID: mdl-17589782
The epididymal beta-defensins have evolved by repeated gene duplication and divergence to encode a family of proteins that provide direct protection against pathogens and also support the male reproductive tract in its primary function. Male tract defensins also facilitate recovery from pathogen attack. The beta-defensins possess ancient conserved sequence and structural features widespread in multi-cellular organisms, suggesting fundamental roles in species survival. Primate SPAG11, the functional fusion of two ancestrally independent beta-defensin genes, produces a large family of alternatively spliced transcripts that are expressed according to tissue-specific and species-specific constraints. The complexity of SPAG11 varies in different branches of mammalian evolution. Interactions of human SPAG11D with host proteins indicate involvement in multiple signaling pathways.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Beta-Defensinas
/
Epidídimo
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Asian J Androl
Asunto de la revista:
MEDICINA REPRODUTIVA
/
UROLOGIA
Año:
2007
Tipo del documento:
Article
Pais de publicación:
China