Identification of immunogenic MHC class II Tyrosinase-derived peptides using HLA-DR1 and HLA-DR4 transgenic mice.

Horton, R B V; Laversin, S A S; Reeder, S P; Rees, R C; McArdle, S E B

Horton, R B V; Laversin, S A S; Reeder, S P; Rees, R C; McArdle, S E B.

Afiliación

Horton RB; The School of Biomedical and Natural Science, Nottingham Trent University, Clifton Campus, Interdisciplinary Biomedical Research Centre, Clifton Lane, Clifton, Nottingham, NG11 8NS, UK.

Protein Pept Lett ; 14(5): 455-60, 2007.

Article en En | MEDLINE | ID: mdl-17584170

RESUMEN

The immunogenicity of "novel" MART-1 and Tyrosinase class-II peptides was assessed in transgenic mice. Tyrosinase(141-161) peptide was found to be immunogenic and endogenously processed in the HLA-DRbeta1*0101 and HLA-DRbeta1*0401 transgenic mice with peptide specific production of IFNgamma or IL-5 respectively. The MART-1(29-43) peptide was only found immunogenic in HLA-DRbeta1*0101 mice.

Asunto(s)

Antígenos HLA/inmunología; Isoantígenos/aislamiento & purificación; Monofenol Monooxigenasa/metabolismo; Linfocitos T/inmunología; Animales; Células Cultivadas; Granulocitos; Antígeno HLA-DR1/inmunología; Antígeno HLA-DR4/inmunología; Melanoma/inmunología; Ratones; Ratones Transgénicos; Monofenol Monooxigenasa/inmunología; Fragmentos de Péptidos/inmunología

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T / Monofenol Monooxigenasa / Antígenos HLA / Isoantígenos Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Protein Pept Lett Asunto de la revista: BIOQUIMICA Año: 2007 Tipo del documento: Article Pais de publicación: Países Bajos

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