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Levels of neuropeptides nocistatin, nociceptin/orphanin FQ and their precursor protein in a rat neuropathic pain model.
Joseph, Tessy; Lee, Tat-Leang; Li, Chunmei; Siau, Chiang; Nishiuchi, Yuji; Kimura, Terutoshi; Tachibana, Shinro.
Afiliación
  • Joseph T; Department of Anaesthesia, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.
Peptides ; 28(7): 1433-40, 2007 Jul.
Article en En | MEDLINE | ID: mdl-17583384
Neuropeptides nociceptin/orphanin FQ (N/OFQ) and nocistatin (NST) are related to pain modulation. The amounts of these peptides and their precursor protein, prepronociceptin (ppN/OFQ) in the brain, spinal cord and serum samples of rats with partial sciatic nerve ligation (PSNL) were compared with those in naïve rats using radioimmunoassay (RIA). There was a significant rise in the levels of ppN/OFQ, N/OFQ and NST in the brains of PSNL rats. Their spinal cords showed significantly increased ppN/OFQ and NST levels but no change in N/OFQ levels. The PSNL rats also had increased serum NST (statistically significant) and N/OFQ (statistically insignificant) with decreased ppN/OFQ suggesting important roles of these peptides in neuropathic pain mechanism.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Precursores de Proteínas / Receptores Opioides / Péptidos Opioides Límite: Animals Idioma: En Revista: Peptides Año: 2007 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Estados Unidos
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Precursores de Proteínas / Receptores Opioides / Péptidos Opioides Límite: Animals Idioma: En Revista: Peptides Año: 2007 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Estados Unidos