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Maternal serum free beta-hCG and PAPP-A in patients with habitual abortion-influence on first-trimester screening for chromosomal abnormalities.
Heinig, J; Steinhard, J; Schmitz, R; Nofer, J-R; Kiesel, L; Klockenbusch, W.
Afiliación
  • Heinig J; Department of Obstetrics and Gynecology, University of Münster, Münster, Germany. heinig@uni-muenster.de
Prenat Diagn ; 27(9): 814-6, 2007 Sep.
Article en En | MEDLINE | ID: mdl-17554803
OBJECTIVE: To explore if maternal serum free beta-hCG and pregnancy-associated plasma protein A (PAPP-A) levels in the first-trimester of pregnancy are altered in patients with habitual abortions and if there is an effect on first-trimester screening for Down syndrome. METHODS: A retrospective study was conducted on 913 normal singleton fetuses that underwent first-trimester combined screening for Down syndrome. Maternal serum PAPP-A and free beta-hCG were compared between patients with (n = 64) and without habitual abortions (n = 849). RESULTS: The medians +/- SD log(10) MoM of PAPP-A and free beta-hCG +/- SD in patients with and without habitual abortions were 0.063 +/- 0.28 versus - 0.014 +/- 0.27 and - 0.001 +/- 0.27 versus - 0.018 +/- 0.31, with a p value of 0.042 and 0.87, respectively. The screen positive rate setting the cut off at 1:350 looking at the background risk for trisomy 21 was 71.4% in women with and 81.2% in women without habitual abortion, after combined first-trimester screening it was 7.8% in women with and 10.1% in women without recurrent abortion. CONCLUSIONS: Patients with habitual abortions have slightly increased maternal serum PAPP-A levels in the first-trimester. This marginal difference seems not to effect risk calculation in combined first-trimester screening for trisomy 21.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína Plasmática A Asociada al Embarazo / Primer Trimestre del Embarazo / Cromosomas Humanos Par 21 / Aborto Habitual / Pruebas Genéticas / Aberraciones Cromosómicas / Gonadotropina Coriónica Humana de Subunidad beta Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Screening_studies Límite: Adolescent / Adult / Female / Humans / Middle aged / Pregnancy Idioma: En Revista: Prenat Diagn Año: 2007 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Buscar en Google
Añadir a Mi BVS
Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína Plasmática A Asociada al Embarazo / Primer Trimestre del Embarazo / Cromosomas Humanos Par 21 / Aborto Habitual / Pruebas Genéticas / Aberraciones Cromosómicas / Gonadotropina Coriónica Humana de Subunidad beta Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Screening_studies Límite: Adolescent / Adult / Female / Humans / Middle aged / Pregnancy Idioma: En Revista: Prenat Diagn Año: 2007 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido