Evaluation of naked eye single tube red cell osmotic fragility test in detecting beta-thalassemia trait.
Indian Pediatr
; 28(5): 469-72, 1991 May.
Article
en En
| MEDLINE
| ID: mdl-1752672
The Naked Eye Single Tube Red Cell Osmotic Fragility Test (NESTROFT) was applied to 4 groups of subjects: (i) Normal; (ii) Proven beta-thalassemia trait carriers; (iii) Iron deficiency anemia; and (iv) other hemoglobinopathies, to evaluate its effectiveness as a screening test for beta-thalassemia minor. The test was successful in detecting 105/110 subjects with beta-thalassemia trait. The sensitivity of the test was 95.5% and specificity was 87%. The predictive value of the positive test was 70.5% and that of the negative test was 98.3%. NESTROFT was also positive in 9/17 subjects with HbS trait, in 3/3 subjects with HbD trait and in 1/1 subjects with HbE trait. The test proved to be simple, cheap, easy to perform and adaptable for field surveys, coming close to an ideal screening test for beta-thalassemia minor.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Talasemia
/
Eritrocitos
/
Pruebas Hematológicas
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Prognostic_studies
Límite:
Child
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Indian Pediatr
Año:
1991
Tipo del documento:
Article
Pais de publicación:
India