Your browser doesn't support javascript.
loading
Fibroblast growth factor 20 gene and Parkinson's disease in the Japanese population.
Satake, Wataru; Mizuta, Ikuko; Suzuki, Satoko; Nakabayashi, Yuko; Ito, Chiyomi; Watanabe, Masahiko; Takeda, Atsushi; Hasegawa, Kazuko; Sakoda, Saburo; Yamamoto, Mitsutoshi; Hattori, Nobutaka; Murata, Miho; Toda, Tatsushi.
Afiliación
  • Satake W; Division of Clinical Genetics, Department of Medical Genetics, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan.
Neuroreport ; 18(9): 937-40, 2007 Jun 11.
Article en En | MEDLINE | ID: mdl-17515805
A genetic association between the fibroblast growth factor 20 (FGF20) gene and Parkinson's disease has been found by the pedigree disequilibrium test. This association, however, was not replicated by a case-control association study. In order to clarify the association between the FGF20 gene and Parkinson's disease, we attempted to replicate this association by a case-control association study using a large number of Japanese samples (1388 patients and 1891 controls). rs1721100 exhibited a significant difference in allele C versus G (P=0.0089), and in genotype CC+CG versus GG (P=0.0053). Haplotype association analysis showed that haplotype 2 was the protective haplotype for Parkinson's disease (permutation-P=0.0075). These results suggest that the FGF20 gene is a susceptibility gene for Parkinson's disease in the Japanese population.
Asunto(s)
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Factores de Crecimiento de Fibroblastos Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Neuroreport Asunto de la revista: NEUROLOGIA Año: 2007 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Factores de Crecimiento de Fibroblastos Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Neuroreport Asunto de la revista: NEUROLOGIA Año: 2007 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido