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Effect of a low-dose oral contraceptive on venous endothelial function in healthy young women: preliminary results.
Giribela, Cassiana Rosa Galvão; Rubira, Marcelo Custódio; Melo, Nilson Roberto de; Plentz, Rodrigo Della Méa; Angelis, Katia de; Moreno, Heitor; Consolim-Colombo, Fernanda Marciano.
Afiliación
  • Giribela CR; Hipertension Unit, Heart Institute, Medical School, São Paulo University, São Paulo, SP, Brazil.
Clinics (Sao Paulo) ; 62(2): 151-8, 2007 Apr.
Article en En | MEDLINE | ID: mdl-17505700
BACKGROUND: A possible increase in the incidence of venous thromboembolic events has been reported among users of third generation oral contraceptives. The objective of this study was to evaluate the effect of a low dose oral contraceptive (15 microg ethinyl estradiol/60 microg gestodene) on the venous endothelial function of healthy young women. METHODS: Prospective case control study using the dorsal hand vein technique. Venous endothelial function was evaluated at baseline and after 4 months in the oral contraceptive users group (11 women) and in a control group (9 women). After preconstriction of the vein with phenylephrine, dose-response curves for acetylcholine and sodium nitroprusside were constructed. RESULTS: In the contraceptive users group, a reduction occurred in the maximum venodilation response to acetylcholine and sodium nitroprusside after 4 months of oral contraceptive use, but this difference was not statistically significant (P > 0.05). No significant changes were detected in maximum venodilation responses to acetylcholine and sodium nitroprusside at the 4-month time point in the control group. CONCLUSION: This study found no significant impairment of endothelium-dependent or independent venodilation in healthy young women following oral contraceptive use. Further studies are necessary using the same methodology in a larger sample over a longer follow-up period.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasodilatación / Endotelio Vascular / Anticonceptivos Orales Combinados / Trombosis de la Vena Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Adolescent / Adult / Female / Humans Idioma: En Revista: Clinics (Sao Paulo) Asunto de la revista: MEDICINA Año: 2007 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasodilatación / Endotelio Vascular / Anticonceptivos Orales Combinados / Trombosis de la Vena Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Adolescent / Adult / Female / Humans Idioma: En Revista: Clinics (Sao Paulo) Asunto de la revista: MEDICINA Año: 2007 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos